Determination of In-vitro Anticancer activity of ‘’Vembu Karpam’’- a hundred years old bark based Siddha Medicine

  • Vinutha T
  • Gowtham Kumar S
  • Manekshah YR
  • Subash Chandran G
DOI: https://doi.org/10.124583/jrbms.v1i1.20
Keywords: Vembu karpam, Siddha medicine, Siddha cancer therapy, Lung cancer

Abstract

Abstract

Background

Vembu Karpam is a Siddha medicine which is primary composed of Vembu, which is collected from 100 years old tree. It is primarily used for Uthiravatha Suronitham (Rheumatoid Arthritis) and the anticancer profile of this neem plant is no way newer and having potential cancer properties. Cancer still remains the major cause of mortality and morbidity all over the world. In the search of potential anticancer agents from the herbal origin, the present research work was carried out to examine the anticancer properties of  Vembu karpam

Objective

The objective is to determine the cytotoxic effect of the siddha herbal formulation Vembu Karpam.

Methods

 In this study we selected two cancerous cell lines (Lung cancer A549, Breast cancer MCf-7) were studied the effect of the Vembu karpam  which is majorly originated from Azadirachta indica on the cell lines and accessed through MTT assays.

Results

Results showed the potent anticancer effect of  Vembu Karpam  in A549 shows LD50 in 71.57 µg/ml  and MCf50 shows LD 50 value as 39.78 µg/ml on human cancer cell lines Lung and Breast cells respectively.

Conclusion

The findings from this study indicated that the herbal medicine Vembu Karpam has potential as a medicinal drug especially in breast cancer and lung cancer treatments.

References

1. World health organization regional office for the western pacific, Research guidelines for evaluating the safety and efficacy of herbal medicines. Manila, World Health organization regional office for the western pacific, 1993.
2. T. Jayashree, K. K. Kishore, M. Vinay, P. Vasavi, N. Chandrashekhar, V. S. Manohar, R. Dixit, Journal of Clinical& Diagnostic Research, 2011, 5(3), 578-582.
3. D. Jeya Sheela Jeeva, I. M. Ramzan Shamila, N. C. J. Packia Lekshmi and J. Raja Brindha, Asian J.Plant Sci and Res, 2012, 2 (1), 41-44.
4. W. B. Hugo, A. D. Russel, Pharmaceutical Microbiology, Blackwell Scientific Publications, Third edition, 1984, 179-200.
5. Niles AL, Moravec RA, Riss TL. Update on in vitro cytotoxicity assays for drug development. Expert Opin Drug Discov 2008; 3(6):655-69.
6. Niles AL, Moravec RA, Riss TL. In vitro viability and cytotoxicity testing and same-well multi-parametric combinations for high throughput screening. Curr Chem Genomics 2009; 3:33-41.
7. Fadeyi SA, Fadeyi OO, Adejumos AA, Okoro C, Myles EL. 2013 In vitro anticancer screening of 24 locally used Nigerian medicinal plants. BMC Compl and Altern Med 2013; 13: 7952
Published
2019-05-28
How to Cite
1.
T V, S GK, YR M, G SC. Determination of In-vitro Anticancer activity of ‘’Vembu Karpam’’- a hundred years old bark based Siddha Medicine. J Res Bio Med Sci [Internet]. 2019May28 [cited 2026Mar.6];1(1):37-1. Available from: http://biosci.in/index.php/jrbms/article/view/20
Issue
Vol 1 No 1 (2019): Jan-Mar
Section
Articles

Copyright and Licensing

For all articles published inJRBMS journal, copyright is retained by the authors. Articles are licensed under an open access Creative Commons CC BY 4.0 licenses, meaning that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. These conditions allow for maximum use and exposure of the work, while ensuring that the authors receive proper credit.

In exceptional circumstances articles may be licensed differently. If you have specific condition (such as one linked to funding) that does not allow this license, please mention this to the editorial office of the journal at submission. Exceptions will be granted at the discretion of the publisher.

Reproducing Published Material from other Publishers

It is absolutely essential that authors obtain permission to reproduce any published material (figures, schemes, tables or any extract of a text) which does not fall into the public domain, or for which they do not hold the copyright. Permission should be requested by the authors from the copyright holder (usually the Publisher, please refer to the imprint of the individual publications to identify the copyright holder).

Permission is required for:

  1. Your own works published by other Publishers and for which you did not retain copyright.
  2. Substantial extracts from anyones' works or a series of works.
  3. Use of Tables, Graphs, Charts, Schemes and Artworks if they are unaltered or slightly modified.
  4. Photographs for which you do not hold copyright.

Permission is not required for:

  1. Reconstruction of your own table with data already published elsewhere. Please notice that in this case you must cite the source of the data in the form of either "Data from..." or "Adapted from...".
  2. Reasonably short quotes are considered fair use and therefore do not require permission.
  3. Graphs, Charts, Schemes and Artworks that are completely redrawn by the authors and significantly changed beyond recognition do not require permission.

Obtaining Permission

In order to avoid unnecessary delays in the publication process, you should start obtaining permissions as early as possible. If in any doubt about the copyright, apply for permission. IJRPHR cannot publish material from other publications without permission.

The copyright holder may give you instructions on the form of acknowledgment to be followed; otherwise follow the style: "Reproduced with permission from [author], [book/journal title]; published by [publisher], [year].' at the end of the caption of the Table, Figure or Scheme.