Journal of Research in Biomedical Sciences <p>Biomedical Research is a scientific open access journal that specifies and describes the development activities conducted in the field of biomedicine research. This journal encompasses the study related to microbiology, biochemistry, clinical, medical, computational and engineering aspects relevant to biomedical sciences. Articles will be also considered from related analysis from cell biology, developmental biology, translational medicine, biomedical research, biomedicine, biomedical science, biomedical informatics, biomedical diagnostics, biomedical ethics, biomedical therapy, medical research, clinical research, physiology, pharmacology, reverse pharmacology, Systems and networking pharmacology, TCAM, personalized medicine disciplines.&nbsp;Submission of important articles containing advanced research output aiding in forwarding the subject are most welcome. 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Please notice that in this case you must cite the source of the data in the form of either "Data from..." or "Adapted from...".</li> <li>Reasonably short quotes are considered&nbsp;<em>fair use</em>&nbsp;and therefore do not require permission.</li> <li>Graphs, Charts, Schemes and Artworks that are completely redrawn by the authors and significantly changed beyond recognition do not require permission.</li> </ol> <p><strong>Obtaining Permission</strong></p> <p>In order to avoid unnecessary delays in the publication process, you should start obtaining permissions as early as possible. If in any doubt about the copyright, apply for permission. IJRPHR cannot publish material from other publications without permission.</p> <p>The copyright holder may give you instructions on the form of acknowledgment to be followed; otherwise follow the style: "Reproduced with permission from [author], [book/journal title]; published by [publisher], [year].' at the end of the caption of the Table, Figure or Scheme.</p> Heavy Metal Analysis of Velvanga Parpam by ICP – OES <p><strong>Introduction : </strong>Siddha system of medicine is an ancient health system<strong>.</strong>Velvangam is one of the metal used in siddha system. Velvanga Parpam is&nbsp; one among them used for the treatment of diseases like diabetes mellitus, respiratory infections and etc.</p> <p><strong>Aim:</strong>The main aim of the study is to analyze the heavy metals in the specific preparation of Velvanga Parpam.</p> <p><strong>Materials and Methods: </strong>The Drug Velvangam is purified and prepared as medicine as per siddha text. MP is subjected to ICP-OES analysis in the instrument Perkin Elmer optima 5300DV.</p> <p><strong>Result:</strong> The result indicates the presence of the elements&nbsp; Phosphorus and Tin.Tin has its highest concentration of <strong>441.210mg/L</strong>.</p> <p><strong>Discussion:</strong> It proves that a PARPAM is mainly composed of the element Tin and phosphorus .</p> <p><strong>Conclusion : </strong>This concludes that, the Velvanga Parpam is free from heavy metals and safer for human consumption. Mainly composed of the element TIN. Further&nbsp; studies on Velvanga Parpam is needed to strengthen its safety and efficacy.</p> Muniyappan P Rishi Priya CR Kingsly A Copyright (c) 2023 Journal of Research in Biomedical Sciences 2023-07-05 2023-07-05 5 2 324 326 10.124583/jrbms.v5i2.121 A Review on Medicinal Plants Used in the Management of Kuruthiazhal (Hypertension ) in Siddha System <p>The Siddhars classified the disease into 4448. In Siddha system of medicine, the symptoms of <em>Kuruthiazhal(Rathapitham) </em>may be correlated with Hypertension mentioned in&nbsp; Noikalukku Siddha parikaram. Although Siddha system is stuffed with more information on above fields there is a lack of scientific based evidence, and Siddha classical literature searches dragging its height.To attract the view of scientific world it is needed to prove our medicine with valid updation. To attain this a comprehensive researched literature review is needed. This is my first step to compile all the necessary information about plants for kuruthiazhal based on taste.</p> Madeshwari K Kingsly A Copyright (c) 2023 Journal of Research in Biomedical Sciences 2023-07-05 2023-07-05 5 2 327 337 10.124583/jrbms.v5i2.122 Biochemical Analysis of Siddha Drug “Uppu Parpam” <p>In the Siddha system, various effective Siddha drugs are mentioned in classical Siddha texts and manuscripts written by ancient Siddhar scientists who introduced it in India.Therefore identification and scientific validation of an effective Siddha drug to prevent and control the Paarisa vaayu (stroke or hemiplegia) is very essential in this current world.The symptoms of ‘paarisa vayu’ may be correlated with the symptoms of Hemiplegia in the modern medicine. Hemiplegia means paralysis one half of the body including lower half of the face, upper and lower extremities due to opposite side pyramidal lesion. The most common cause of Hemiplegia is Stroke, which damages the corticospinal tracts in one of the hemisphere of the brain. Other causes of hemiplegia include trauma, spinal cord injury, brain tumors and brain infections.So, I have selected a <strong>“UPPU PARPAM”</strong> is a poly mineral formulation which is exclusively indicated for Paarisa Vayu (hemiplegia) which is mentioned in Siddha literature of <strong>Kannusamy Parambarai Vaithiyam Pg.No.353.</strong> It was determined that<em> Uppu parpam</em> contains calcium, sulphate, chloride, carbonates, and ferrous iron, which improved therapeutic action based on biochemical analysis.</p> Marijothi M Kingsly A Copyright (c) 2023 Journal of Research in Biomedical Sciences 2023-07-10 2023-07-10 5 2 338 342 10.124583/jrbms.v5i2.123 Biochemical Analysis of Siddha Polyherbal Drug Thathu Pushti Chooranam <p>The Siddha system of medicine is a traditional medical system which relies on fundamental principles such as <em>Pancha boothas</em> (fire, water, air, earth and space) and 96 <em>thathuvas</em>. According to this system there are three vital life factors (<em>Vatham</em>, <em>pitham</em> and <em>kabam</em>) which were responsible for good health. The polyherbal formulation <em>Thathu pushti chooranam</em> is a classic Siddha medicine which was mentioned in <em>Anuboga vythia brama rahasiam</em> (part 6) for <em>thathu pushti</em> and <em>balam</em>. Infertility is the inability of a sexually active, non-contracepting couple to achieve pregnancy in one year. Infertility is a commonly encountered problem in approximately 15% of couples who wish to conceive. In the male reproductive system, infertility is most commonly caused by problems in the ejection of semen, absence or low levels of sperm, or abnormal shape (morphology) and movement (motility) of the sperm. Decreased number of spermatozoa (oligozoospermia), decreased motility (asthenozoospermia) and many abnormal forms on morphological examination (teratozoospermia), usually these abnormalities come together and are described as the oligo-astheno-teratozoospermia (OAT) syndrome which are all one of the causes for infertility. The objective of the study is to evaluate the compounds present in the polyherbal Siddha formulation <em>Thathu pushti chooranam. </em>The biochemical analysis of <em>Thathu pushti chooranam</em> reveals the presence of &nbsp;ferrous iron, amino acid and chloride. The compounds present in the <em>chooranam</em> will enhance the therapeutic action of the drug.</p> Swathidharsini R Antony Duraichi R Copyright (c) 2023 Journal of Research in Biomedical Sciences 2023-07-10 2023-07-10 5 2 343 350 10.124583/jrbms.v5i2.125 Qualitative and Quantitative analysis of “Nanguneri Ennai” (Effective Treatment for Psoriasis) as mentioned in Siddha Literature <p>The Siddha system of medicine is an unique medical philosophy originated from South India.A wide variety of skin diseases have been explained in Siddha literature.It is classified into 18 types which includes whole range of skin diseases.Siddha system has a effective management in auto immune disorders especially Psoriasis(<em>Kalanjagapadai)</em>.Several medications are very effective in treating <em>Kalanjagapadai</em> especially <em>Nanguneri Ennai </em>from (<em>Agasthiyar paripooranam 400</em>) mentioned in <strong><em>Siddha</em></strong> <strong><em>maruthuvam sirappu</em></strong> by Thiyagarajan .The oil accumulated in the well of <em>Ananthasayanar temple </em>at Nanguneri contains materials of abishegam and various other holy things which pass through an channel and gets accumulated in well.Patients suffering from skin disease gets benifitted by applying oil externally and to be washed with green gram powder.This study is aimed at validating the components of <em>Nanguneri ennai.</em>Qualitative and quantitative analysis of sample was done in laboratory by ICP-OES,FTIR ,GCMS And Physico Chemical Analysis methods. The result obtained from ICP-OES indicates the presence of elements like sulphur, phosphorous and carbon and&nbsp; results from FTIR analysis indicates the presence of certain functional groups like alkyl aryl ether, Isothiocynate, halo compounds, and amine salts. GCMS analysis indicates the presence of components like 4,4 diethyl amino acid,cyclopentano propionic acid etc,The presence of certain&nbsp; elements in the sample containing activities like anti-inflammatory, emolient and anti-septic helps in management of psoriasis on topical application.</p> Narmadha KN Essakkypandian G Kingsly A Copyright (c) 2023 Journal of Research in Biomedical Sciences 2023-07-10 2023-07-10 5 2 351 356 10.124583/jrbms.v5i2.126 Biochemical Analysis of Siddha Mineral Drug Vedikara Silasathu Parpam <p>Siddha System is one of the oldest system of medicine in India. It includes 32 internal medicine and 32 external medicine , totally 64 types of medicine . <em>Vedikara silasathu parpam</em> is one of the internal medicine mentioned in the literature “ Kannusaamiyam parambarai vaithiyam ” which is indicated for <em>Neerkattu</em>. Siddhars&nbsp; had classified the diseases into 4448 types. <em>Yugi </em>&nbsp;had classified urinary disorder into two, <em>Neerinai arukkal noigal </em>and<em> Neerinai perukkal noigal</em><em>, Neerkattu </em>&nbsp;comes under <em>Neerinai arukkal noikal.</em>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p> <p>Anuria or anuresis means suppression of urine. It may result from blocking of tubules of the kidney, gross obstruction to the urinary tract or rapid fall of blood pressure. The aim of the study was to evaluate the biochemical analysis of the drug <em>Vedikara silasathu parpam </em>and it indicates the presence of&nbsp; Calcium, Sulphate, Chloride, Carbonates And Ferrous Iron which revealed the enhancement of therapeutic action. Drug with Proper scientific evidence will be beneficial for the mankind in future. &nbsp;&nbsp;</p> Jayapriya K Kingsly A Copyright (c) 2023 Journal of Research in Biomedical Sciences 2023-07-10 2023-07-10 5 2 341 345 10.124583/jrbms.v5i2.124 Standardization of Anda Thailam as per Siddha Literature and through a Scientific Technique ICP-OES, FTIR and Physico-Chemical Analysis <p><strong>Aim and Objective: </strong>The aim of the study is to validate the heavy metal analysis of a Siddha formulation “<em>Anda Thailam” (AT) </em>through a scientific technique inductively coupled plasma optical emission spectrometric analysis (ICP-OES), FTIR and PHYSICO CHEMICAL ANALYSIS was done in sophisticated analytical instrument facility IITM, Chennai-36. “<em>Anda Thailam” </em>is one of the Siddha drug chosen from the Siddha classical literature <em>Noi neekum thailangal by Siddha saraba naagai shanmugaanantha swamikal,for &nbsp;&nbsp;Mantham ,Sanni, Valippu and Pakkavatham</em> <em>&nbsp;page no:95 </em>There is a necessary for the analysis of heavy metal analysis before implementation of the trial drug to the clinical trial. Thus an attempt was made to screen the heavy metal analysis of the Siddha preparation of “<em>Anda Thailam” </em>through the scientific method of ICP-OES analysis of indicates the presence of Carbon-11.234mg/L, Calcium-02.180mg/L, Chlorine-01.100mg/L, Iron-03.376mg/L, Phosphorus-106.341mg/L, Sulfur-01.254mg/L and Zinc-01.018mg/L. In FTIR the&nbsp;&nbsp; functional groups such as halo compounds and Alcohol were presents in the Anda thailam can be correlated with the management of <em>Pakkavatham,Sanni</em> and <em>Mantham.</em></p> Murali M Essakkypandian G Copyright (c) 2023 Journal of Research in Biomedical Sciences 2023-07-10 2023-07-10 5 2 357 361 10.124583/jrbms.v5i2.127 ICP –OES Analysis of Cheenalinga Chendooram <p>Siddhars knowledge about various herbs, metals and minerals are still undiscovered by the scientific world. It is mystery to the scientific society to evaluate the extraction of&nbsp; a herbo – mineral formulation. Often medicines like parpam and chendooram in Indian system of medicine are frequently reported with heavy metal content above permissible limits by the western science according to siddha literature Cheenalinga Chendooram is a mineral medicine used in the treatment of Keelvayu (Arthritis).</p> <p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; It has been decided to standardize the Cheenalinga Chendooram which is prepared as per the siddha literature Anuboga Vaithiya Navaneetham. The present study gains its own importance in the scientific society being focused on the analysis of heavy metal content in the siddha medicine Cheenalinga Chendooram using inductively coupled plasma optical emission spectrometry (ICP-OES) carried out at Sophisticated Analytical Instrument facility IITM, Chennai -36.</p> Rajini Srikajan Essakkypandian G Copyright (c) 2023 Journal of Research in Biomedical Sciences 2023-07-10 2023-07-10 5 2 362 365 10.124583/jrbms.v5i2.128 Analysis and Characterization of the Traditional Siddha formulation Suvasa Kudori Chenduram through Fourier Transform Infra-Red Spectroscopy <p><em>Suvasa kudori chenduram</em> is one of the traditional Siddha medicine used specially for Bronchial asthma. Siddha medicines has high therapeutic value but standardization is very essential nowadays to get wider knowledge of the drug for safer use. Characterization paves a major role for the standardization of the drug. FTIR characterization will help to determine the functional group present in the drug.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;<em>Suvasa kudori chenduram</em> was prepared according to literature and subjected into characterization through FTIR instrument and it revealed the presence of functional groups O-H,S=C, P-H, NCO,CN,N=C=S, C=O,C=C respectively. It indicates the presence of functional groups primary amines, amine salt, alcohol, thiol, isothiocyanate, anhydride, conjucated anhydrite, oxime, nitro compound, aldehyde, sulfonyl chloride, alkene, halo compound, aliphatic amides. These functional groups has immune modulatory, broncho dilator, analgesic, anti-bacterial activities, which helps in the treatment in Bronchial asthma.</p> Selvi T Antony Duraichi R Copyright (c) 2023 Journal of Research in Biomedical Sciences 2023-07-10 2023-07-10 5 2 366 370 10.124583/jrbms.v5i2.129 Preliminary Phytochemical, Physicochemical and Biochemical Characterizations of Herbal Formulation of Vishnukiranti Kudineer ( Evolvulus Alsinoides). <p>The siddha system of medicine is one among AYUSH system in India. The siddha medicine is used to treat various diseases,especially in vatha disease. Siddha system concept is spreading a healthy soul in a healthy body. Ceganavatham (cervical spondylosis) is one of the common degenerative condition &nbsp;in cervical ribs, which move unable to move the neck and hands. The vishnukiranti kudineer (Evolvulus alsinoides) Convolvulaceae family is indicated for the ceganavadham in gunapadam part-1 (Mooligai vaguppu).It is a perennial herb sound throughout India. The drug has various pharmacological activities like anti- inflammatory,anti-viral,anti-cancer,anti-oxidant and analgesic activity.<strong>Aim:</strong>The aim of the study is to perform qualitative phytochemical evaluation, biochemical analysis and physico chemical analysis of vishnukiranti kudineer. <strong>Material and methods : </strong>The raw drug vishnukiranti (whole plant) was bought from reputed herbal drug shop, Thackkalay Kanyakumari, and it is purified and made into decoction as per the siddha literature. <strong>Results: </strong>The phytochemical evaluation showed Terpenoids, alkaloids, glycosides, quinones, proteins. The biochemical analysis showed the presence of sulphate, chloride, Tannic acid, unsaturated compound,reducing sugar.The Physico chemical compounds are total ash 9.95% Acid insoluble ash 1.01%, Water soluble ash 1.78%, Sulphate ash 16.25%, Alcohol soluble extracts 10.38%, Water soluble extracts 11.11%.</p> Sarumathi S Komalavalli T Manoharan A Copyright (c) 2023 Journal of Research in Biomedical Sciences 2023-07-10 2023-07-10 5 2 371 375 10.124583/jrbms.v5i2.130 ICP –OES Analysis of Silasathu parpam <p>Siddha system of medicine is one of the oldest medicinal technique known to mankind known to be originated from South India. Siddha system is based on <em>naadi ,pancha bootha, suvaigal</em> and <em>thegigal</em>. Any derangement to these basic principle may lead to disease in humans. The herbomineral formulation Siddha drug <em>Silasathu parpam</em> contains styptic activity used in the treatment of bleeding piles and its associated symptoms like itching around anus, pain in anal region, bleeding during bowel movements etc. Bleeding piles is more prevalent among people in developing countries. The objective of study is to evaluate the components in <em>Silasathu parpam</em>. <em>Silasathu </em>(Gypsum) is a soft sulfate mineral. It is widely used as traditional medicine for urinary tract infections, leucorrhoea, bleeding piles, etc. I have selected <em>Silathu parpam</em> for bleeding piles. It is composed of calcium sulfate dihytrate Caso4.2H<sub>2</sub>O.The present study gain its own important in scientific society being focus analysis of heavy&nbsp; mineral content in Siddha medicine&nbsp; <em>Silasathu parpam</em>.</p> Seetha M Antony Duraichi R Copyright (c) 2023 Journal of Research in Biomedical Sciences 2023-07-10 2023-07-10 5 2 376 378 10.124583/jrbms.v5i2.131 Siddha management for Squamous cell Gingivobuccal carcinoma (Kannaputru) reporting at cancer special OPD of National Institute of Siddha-A single case report <p>Cancer is the second leading cause of death globally and is responsible for an estimated 9.6 million deaths in 2018.&nbsp;Owing to the importance and benefits of traditional medicine, the WHO has included integrative oncology as one of the primary objectives of the treatment of cancer besides cure, prevention of recurrence, prolongation of life, re-habitation and improvement of Quality of life. In National Institute of Siddha, the special OPD for cancer is conducted on every Wednesday. There are approximately 50 patients reported here for various cancers like breast cancer, cervical cancer, stomach cancer, ano rectal cancer, oral cancer, tongue cancer, urinary bladder cancer etc., Palliative patients who visit NIS, often have multiple symptoms, ranging from physical (pain, nausea, loss of appetite and shortness of breath) to psychological (anxiety and depression). Siddha medicines manage these symptoms effectively, reduces the side effects of medications and cancer-associated complications. This paper focuses on “A single case of gingivo buccal carcinoma taking Siddha treatment at cancer special OPD of National Institute of Siddha.</p> Siva Lakshmi S Vetha merlin kumari H Nalini Sofia H Lakshmi kantham T Meenakumari R Copyright (c) 2023 Journal of Research in Biomedical Sciences 2023-06-30 2023-06-30 5 2 379 382 10.124583/jrbms.v5i2.132