Evaluation of In-vivo anti-inflammatory and In-vitro Immunomodulatory activity of a Siddha drug, Rajaloga Naatharasa Parpam
Abstract
Introduction
The metallo-mineral based anti-inflammatory drugs are the current need for the healthcare and current world depends on more that 80% of peoples used the herb based drug for their primary clinical needs. The present study is needed due to the gradient rise of Rheumatological disorders globally due to its lifestyle changes. To overcome this, immunomodifier is also essential for this case.
Methods
The anti-inflammatory and Immunomodulatory action of the drug Rajaloga naatharasa parpam was studied using carrageenan induced inflammatory study and Immunomodulatory studies using RAW 264.7 cells
Results
In the carrageen induced anti-inflammatory activity, the drug Rajaloga naatharasa parpam showed an significant decrease in the paw edema volume in animal models with dose of 100mg/kg and 200mg/kg in rats where indomethacin were used as a standard.. Then paw volume is siginificant of ∗∗ p < 0.01 when compared to control. The Immunomodulatory action in RAW 264.7 cells shows a significant reduction in nitrate level which reduces further inflammations.
Conclusion
Rajaloga naatharasa parpam showing a potent effect in engulfing inflammation and provokes immunity as well and this could be used for the treatment of musculoskeletal disorders.
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