Investigation of Anti-ulcer effect of Siddha formulation Pancha Lavana Dravagam on Albino rats
Abstract
Pancha Lavana Dravagam (PLD) is a poly mineral siddha formulation used for treating gastritis and dyspepsia. The present study was carried out to investigate the anti-ulcer effect of PLD (1 ml/kg, p.o and 2 ml/kg, p.o) in gastric ulcer. The study was carried out using pyloric ligation induced gastric ulcer in albino rats. The anti-ulcer activity of PLD (1 ml/kg, p.o and 2 ml/kg, p.o, for 7 days) was compared with standard drug (Ranitidine 50 mg/kg, p.o). The parameters like gastric volume, pH, total acidity, free acidity, ulcer index and percentage ulcer protection were studied using this pyloric ligation method. In pyloric ligation model, there was a significant decrease in the ulcer index, gastric volume, total and free acidity in the PLD treated groups. There was a significant increase in the percentage protection of gastric ulcers and pH of the gastric juice in PLD treated groups when compared to the disease control groups. The results obtained from the study indicate that the test drug PLD has potent anti-ulcer activity mediated by its acid neutralizing property and anti-secretory property. Hence it supports the scientific claim behind the traditional medicine.
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