Evaluation of Anti-inflammatory and analgesic properties of Siddha classical medicine Changan Ilai Kudineer

  • Vinutha T
  • Gowtham Kumar S
  • Manekshah YR
  • Subash Chandran G
DOI: https://doi.org/10.124583/jrbms.v1i2.21
Keywords: Siddha medicine, Changan ilai, Anti inflammatory in Siddha

Abstract

Background

Plants have played a central role in the prevention and treatment of diseases since prehistoric times. In recent years, there has been growing interest in the study of medicinal plants based medicines of Siddha medicines. The same scenario has extensive in different countries. However, today it is essential to pay for the scientific proof for each and every formulation in the traditional Siddha medicine.

Objectives

The core objective is to evaluate the therapeutic potential of Changan Ilai Kudineer for its Anti inflammatory and analgesic activities.

Methodology:

Anti-inflammatory activity on changan ilai kudineer was studied using carrageenan-induced paw edema method with dose of   100mg/kg and 200mg/kg in rats. The dose determination studies were carried out according to OECD guidelines and based on our previous acute toxicity study. Hence, 100 & 200 mg/kg was given for the models for analgesic  activity through acetic acid-induced writhing reflux in mice.

Results:

The percentage reduction of paw volume against Carrageenan induced paw oedema was more than 50% and the analgesic activity was also in a significant levels.

Conclusions:

 Our findings confirmed that the antiinflammatory, analgesic activities of Changan ilai Kudineer could be beneficial for the treatment of Arthritis and associated symptoms.

References

1. T.V.Sambasivampillai, Tamil-English dictionary of Medicine, Chemistry, Botany and Allied sciences, first edition-1931, .Directorate of Indian medicine and homoeopathy,(1994).
2. Athma Ratchamirtham Ennum Vaithya Saarasangiragam, KandasamyMudaliar,1 Edition September 2011,pgno 485.
3. Shashikant V. Bhandari, Kailash G. Bothara, Mayuresh K. Raut, Ajit A. Patil, Aniket P. Sarkate and Vinod J. Mokale. Design, Synthesis and Evaluation of Antiinflammatory, Analgesic and Ulcerogenicity studies of Novel S-Substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of Diclofenac acid as Nonulcerogenic Derivatives, Bioorganic & Medicinal Chemistry, 16 (2008) 1822–1831.
4. Bennett RN, Mellon FA, Rosa EA, Perkins L, Kroon PA. Profiling glucosinolates, flavonoids, alkaloids, and other secondary metabolites in tissues of Azima tetracantha L. (Salvadoraceae). J Agric Food Chem 2004;52:5856-62.
5. Rall GJH ST, De Waal HL, Arndt RR. Dimeric piperidine alkaloids from Azima tetracantha. Tetrahedron Letts 1967:3465-9.
6. S WUaN. Isorhamnetin-3-Orutinoside from leaves of Azima tetracantha Lam. Ind J Chem 1998;27:387.
7. PRS RVaPR. Occurrence of triterpenoids in Azima tetracantha. Curr Sci 1978;47:857.
8. Daulatabad CD DV, Hosamani KM, Jawkhande AM. Novel fatty acids in Azima tetracantha seed oil. J A Oil Chem Soc 1991;68:978-9.
9. Siva N GN. Banumathy and muthuchelian antifungal effect of leaf extract of some medicinal plants against Fusarium oxysporum causing wilt disease of Solanum melogena L. Ethnobotanical Leaflets 2008;12:156-63.
10. Aragao Gislei F LMC, Antônio PF Junior, Paulo N Bandeira, Telma LG Lemos, Glauce S de B. Viana Evidence for excitatory and inhibitory amino Acids participation in the neuropharmacological activity of alpha-and beta-amyrin acetate. Open Pharmacol J 2009;3:9-16.
11. Ismail TS GS, Begum VH, Elango V. Anti-inflammatoryactivity of Salacia oblonga Wall and Azima tetracantha Lam. J Ethnopharmacol 1997;56:145-52.
12. Beneficial effect of Inularacemosa(Pushkaramoola) in angina pectoris: a preliminary report. Ind J physiol Paharmacol , 1984, 28, 1, 73-5
13. Mehara, M.M.; Deshpande, K.G.; Ghatag, B.B.;Bhattacharya,S.K. Terpenoids CVTransformation product of an Alantolactone, Tetrahendron 1967,23, 2469-80 .
14. Purushothanman, K.K.; Sarada, A. Chemical examination of substitutes for Pushkaramoola, J Res Indian Med, 1974, 9, 3, 30-32
15. Tripathi, S.N.; Upadhyaya, B.N.; Gupta, V. K. Beneficial effect of Inularacemosa(Pushkaramoola) in angina pectoris: a preliminary report. Ind J physiol Paharmacol, 1984, 28, 1, 73-5
16. Pal, H.C.; Sehar, I.; Bhushan, S.; Gupta, B.Activation of caspases and poly (ADP-ribose)polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inularacemosa, Toxicol in Vitro, 2010,24,1599–1609
17. Zafar, A. M.; Sualeh, S. B. Z. M. Herbal treatment for cardiovascular disease The evidence based therapy, Pak J Pharm Sci2010, 23, 1,119-124
18. Lignans and sesquiterpene lactones from Artemisia Sieversiana and inularacemosa, to check the anti fungal activity, TANG, SHUAI, Elsevier science Ltd, Phytochemistry\ Vol[ 38\ No[ 0\ pp[ 046050\ 088 .
Published
2019-05-28
How to Cite
1.
T V, S GK, YR M, G SC. Evaluation of Anti-inflammatory and analgesic properties of Siddha classical medicine Changan Ilai Kudineer. J Res Bio Med Sci [Internet]. 2019May28 [cited 2025Oct.30];1(2):46-2. Available from: http://biosci.in/index.php/jrbms/article/view/21
Issue
Vol 1 No 2 (2019): Apr-Jun
Section
Articles

Copyright and Licensing

For all articles published inJRBMS journal, copyright is retained by the authors. Articles are licensed under an open access Creative Commons CC BY 4.0 licenses, meaning that anyone may download and read the paper for free. In addition, the article may be reused and quoted provided that the original published version is cited. These conditions allow for maximum use and exposure of the work, while ensuring that the authors receive proper credit.

In exceptional circumstances articles may be licensed differently. If you have specific condition (such as one linked to funding) that does not allow this license, please mention this to the editorial office of the journal at submission. Exceptions will be granted at the discretion of the publisher.

Reproducing Published Material from other Publishers

It is absolutely essential that authors obtain permission to reproduce any published material (figures, schemes, tables or any extract of a text) which does not fall into the public domain, or for which they do not hold the copyright. Permission should be requested by the authors from the copyright holder (usually the Publisher, please refer to the imprint of the individual publications to identify the copyright holder).

Permission is required for:

  1. Your own works published by other Publishers and for which you did not retain copyright.
  2. Substantial extracts from anyones' works or a series of works.
  3. Use of Tables, Graphs, Charts, Schemes and Artworks if they are unaltered or slightly modified.
  4. Photographs for which you do not hold copyright.

Permission is not required for:

  1. Reconstruction of your own table with data already published elsewhere. Please notice that in this case you must cite the source of the data in the form of either "Data from..." or "Adapted from...".
  2. Reasonably short quotes are considered fair use and therefore do not require permission.
  3. Graphs, Charts, Schemes and Artworks that are completely redrawn by the authors and significantly changed beyond recognition do not require permission.

Obtaining Permission

In order to avoid unnecessary delays in the publication process, you should start obtaining permissions as early as possible. If in any doubt about the copyright, apply for permission. IJRPHR cannot publish material from other publications without permission.

The copyright holder may give you instructions on the form of acknowledgment to be followed; otherwise follow the style: "Reproduced with permission from [author], [book/journal title]; published by [publisher], [year].' at the end of the caption of the Table, Figure or Scheme.