Evaluation of a herbo-mineral formulation Pooranathi Chooranam for its anti-inflammatory and analgesic activity in animal models

  • Kalaivani R PG Scholar, Department of Sirappu Maruthuvam, Government Siddha Medical College, Chennai, Tamilnadu, India.
  • Suganya D PG Scholar, Department of Sirappu Maruthuvam, Government Siddha Medical College, Chennai, Tamilnadu, India.
  • Pappa Evangeline T PG Scholar, Department of Sirappu Maruthuvam, Government Siddha Medical College, Chennai, Tamilnadu, India.
  • Mohamed Musthafa M Head of the Department, Postgraduate Department of Sirappu Maruthuvam, Government Siddha Medical College, Chennai, Tamilnadu, India.
  • Sekar G Head of the Department, Postgraduate Department of Pura Maruthuvam, Government Siddha Medical College, Chennai, Tamilnadu, India.
DOI: https://doi.org/10.124583/jrbms.v2i4.46
Keywords: Siddha medicine, Trianthema portulacastrum, Anti inflammatory in Siddha

Abstract

Background

In recent years, Herbals are widely used in traditional medicines as well by the common public. As per WHO reports, it is estimated around 80% of population are adhere to herbal medicines in a global range. Various medicinal compounds were identified in herbals. Those are always considered as safe with great medicinal value. Here the Pooranathu chooranam is studied for its anti-inflammatory and analgesic properties to serve the population in their painful situations.

Objectives

The objective is to assess the therapeutic potential of Pooranathi chooranam for its Anti inflammatory and analgesic activities.

Methodology:

Anti-inflammatory activity on Pooranathi chooranam was studied using carrageenan-induced paw edema method with dose of   100mg/kg and 200mg/kg in rats where indomethacin were used as a standard. The dose determination studies were carried out according to OECD guidelines and based on our previous acute toxicity study. Hence, 200 & 400 mg/kg was given for the models to study the analgesic activity through eddy’s hot plate test and pentazocine (30 mg/kg b.w., i.p.) were used as a standard drug.

Results:

The percentage reduction of paw volume against Carrageenan induced paw oedema was more than the control group and the analgesic activity was also possessed significant activity in higher dose of 400mg/kg gives 7.4±0.46* which is statistically significant with the control group.

Conclusions

The reports of the study confirmed that the drug pooranathi chooranam has potent anti-inflammatory, analgesic activities which could be beneficial for the treatment of pain related musculoskeletal diseases.

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Published
2019-10-23
How to Cite
1.
Kalaivani R, Suganya D, Pappa Evangeline T, Mohamed Musthafa M, Sekar G. Evaluation of a herbo-mineral formulation Pooranathi Chooranam for its anti-inflammatory and analgesic activity in animal models. J Res Bio Med Sci [Internet]. 2019Oct.23 [cited 2025Oct.30];2(4):68-3. Available from: http://biosci.in/index.php/jrbms/article/view/46
Issue
Vol 2 No 4 (2019): Oct-Dec
Section
Articles

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