Therapeutic Effectiveness of a Siddha Polyherbal Formulation Nilavaagai Chooranam: A Drug Review
Abstract
Abstract
Siddha system of medicine is one of the ancient systems of medicine practiced among Tamil speaking community particularly in southern parts of India. The medicines in this system prepared from ingredients which is obtained from herbals, mineral, metals and animal products. “Nilavaagai chooranam” is one of the Sastric Siddha Poly herbal formulation containing 5 herbal ingredients. It is indicated for Eraippu Erumal (Bronchial asthma). This review is aimed to bring out scientific evidence for the therapeutic usage of “Nilavaagai chooranam” in Eraippu Erumal ( Bronchial asthma) and focused on the pharmacological activity responsible for the therapeutic nature of the drug in Eraippu Erumal ( Bronchial asthma) Most of the ingredients used for the preparation of Nilavaagai chooranam have antiasthmatic, antihistamine, anti-inflammatory and immunomodulatory activities. Hence justifying its usage in Eraippu Erumal ( Bronchial asthma)
References
Plants, Second edition, Jodhpur, Agrobios (India), 2013, Pages: 118, 213, 334.
2.Dr.K.M.Nadkarni, Indian Materia Medica, Volume-1, Third edition, 2005, Pages: 286-288, 475, 3, 770.
3. Ahmad N, Fazal H, Abbasi BH, Rashid M, Mahmood T, Fatima N. Efficient regeneration and antioxidant potential in regenerated-tissues of Piper nigrum L. Plant Cell, Tissue and Organ Culture 2010; 102: 129-134.
4. Abbasi BH, Ahmad N, Fazal H, Mahmood T. Conventional and modern propagation techniques in Piper nigrum. J. Med. Plant Res 2010; 4: 007-012.
5.Kim SH, Lee YC. Piperine inhibits eosinophil infiltration and airway hyper responsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model. J Pharm Pharmacol 2009; 61: 353-359.
6. Bang JS, Oh da H, Choi HM, Sur BJ, Lim SJ, et al. Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fbroblast-like synoviocytes and in rat arthritis models. See comment in PubMed Commons below Arthritis Res Ther (2009)11: R49.
7.Sharma S, Kalia NP1, Suden P2, Chauhan PS2, Kumar M1, et al. Protective effcacy of piperine against Mycobacterium tuberculosis. See comment in PubMed Commons below Tuberculosis (Edinb) (2014) 94: 389-396.
8. Kim SH, Lee YC. Piperine inhibits eosinophil infiltration and airway hyper responsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin- induced asthma model. J Pharm Pharmacol (2009), 61(3): 353-359.
9. Jung HW, Yoon CH, Park KM, Han HS, Park YK. Hexane fraction of Zingiberis Rhizoma Crudus extract inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NFkappaB pathway. Food Chemistry and Toxicology. 2009; 47(6):1190-1197.
10. Kiuchi F, Iwakami S, Shibuya M, Hanaoka F, Sankawa U. Inhibition of prostagndin leukotriene biosynthesis by gingerols and diarylheptanoids. Chemical and Pharmaceutical Bulletin. 1992; 40(2):387-391.
11. Flynn DL, Rafferty MF. Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones. Prostaglandins Leukotrienes and Medicine. 1986; 22:357-360.
12. Lantz RC, Chen G, Sarihan M, Solyom AM, Jolad SD, Timmermann BN. The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine. 2007; 14(2-3):123-128.
13. Chen IN, Chang CC, Ng CC, Wang CY, Shyu YT, Chang TL. Antioxidant and Antimicrobial Activity of Zingiberaceous Plants in Taiwan. Plants Foods for Human Nutrition. 2008; 63(1):15-20.
14. Imanishi N, Mantani N, Sakai S, Sato M, Katada Y, Ueda K et al. Inducible activity of ginger rhizome (Zingiber officinale Rosc.) on the mRNA expression of macrophage-inducible nitric oxide (NO) synthase and NO production in a macrophage cell line, RAW264.7 cells. American Journal of Chinese Medicine. 2004; 32(5):727-735.
15. Lappas M, Permezel M, Georgiou HM, Rice GE. Nuclear factor kB regulation of proinflammatory cytokines in human gestational tissues in vitro. Biology of Reproduction. 2002; 67(2):668-673.
16.Chrubasik S, Pittler MH, Roufogalis BD. Zingiberis Rhizoma: a comprehensive review on the ginger effect and efficacy profiles. Phytomedicine. 2005; 12(9):684-701.
17. Thomson M, Al-Qattan KK, Al-Sawan SM, Alnaqeeb MA, Khan I, Ali M. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent, Prostaglandins, Leukotrienes & Essential Fatty Acids. 2002; 67(6):475-478.
18. Khaki A, Fathiazad F. Diabetic nephropathy – using herbals in diabetic nephropathy prevention and treatment – the role of ginger (Zingiber officinale) and onion (Allium cepa) in diabetics’ nephropathy. In: Bhattacharya, A. (Ed.), A Compendium of Essays on Alternative Therapy. In Tech Publisher, Rijeka, Croatia. 2012, 207-232.
19. Dugenci SK, Arda N, Candan A. Some medicinal plants as immunostimulant for fish. Journal of Ethnopharmacology. 2003; 88(1):99-106.
20. Puri A, Sahai R, Singh KL, Saxena RP, Tandon JS, Saxena KC. Immunostimulant activity of dry fruits and plant materials used in indian traditional medical system for mothers after child birth and invalids. Journal of Ethnopharmacology. 2000; 71(1-2):89-92.
21. Saeed Alitaneh, and Azam Alavinezhad , Carum copticum L.: A Herbal Medicine with Various Pharmacological Effects hindawi Volume 2014.
22Anupama A., Jadhav Asha S., VaidyaGayatri S., Gailwad Kuldeep D.Anthistaminic and bronchodilating activityof fruit berries of Embelia ribes.International Journal of Pharmacy,3(10):182-184, (2012).
23.K.souravi, P.ERajasekharan review on the pharmacology of embelia ribes burm.f.-a threatened medicinal plan International journal of pharma and bio science 2014 ,5(2) : 443- 456
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